Effect of Physical Activity on Symptoms of Morphine Addiction in Rats, after and before of Lesion of the mPFC Area

نویسندگان

  • Aliasghar Pilehvarian Department of Basic Sciences, Isfahan Payam-e- Noor University, Isfahan, Iran
  • Hojjat Allah Alaei Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  • Vajiheh Saedi-Marghmaleki Department of Basic Sciences, Isfahan Payam -e -Noor University, Isfahan, Iran
چکیده مقاله:

  Objective(s): Drug addiction is one of the fastest growing social problems that researchers, for many years, have been trying to find proper strategies for its prevention and treatment. Short-term physical activity is considered as acceptable for the treatment and prevention of addiction. On the other hand, prefrontal cortex is known to be responsible for many of the complex behavioral responses, especially those relevant to addiction and drug abuse. In this study, the effects of short-term physical activity (treadmill running) on withdrawal symptoms in rats, with or without medial Prefrontal Cortex (mPFC) area was evaluated.   Materials and Methods: In this experimental study, male Wistar rats, weighing 250-300 g. Were selected and divided into four groups: control, sham, test1 and test 2 groups, with one group having a surgery (test 2). In order to study the effects of short-term physical activity, we employed a treadmill with the adjustable speed of 17 m/min, and a 15% incline. Following the injection of three different doses of morphine (10, 20 and 40 mg/Kg) for 9 days, treadmill running was completed on the tenth day and then the symptoms of addiction were evaluated. Results: Administration of morphine as aforementioned, and treadmill running on rats with mPFC area, significantly alleviated some of the symptoms and signs, such as, bruxism, cycling, body lift, licking, standing and scratching (P

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منابع مشابه

effect of physical activity on symptoms of morphine addiction in rats, after and before of lesion of the mpfc area

objective(s): drug addiction is one of the fastest growing social problems that researchers, for many years, have been trying to find proper strategies for its prevention and treatment. short-term physical activity is considered as acceptable for the treatment and prevention of addiction. on the other hand, prefrontal cortex is known to be responsible for many of the complex behavioral response...

متن کامل

Effect of Physical Activity on Symptoms of Morphine Addiction in Rats, after and before of Lesion of the mPFC Area

OBJECTIVE(S) Drug addiction is one of the fastest growing social problems that researchers, for many years, have been trying to find proper strategies for its prevention and treatment. Short-term physical activity is considered as acceptable for the treatment and prevention of addiction. On the other hand, prefrontal cortex is known to be responsible for many of the complex behavioral responses...

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عنوان ژورنال

دوره 16  شماره 10

صفحات  1095- 1099

تاریخ انتشار 2013-10-01

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